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Multiple myeloma is a fatal hematologic malignancy associated with clonal expansion of malignant plasma cells within the bone marrow and the development of a destructive osteolytic bone disease. The principal cellular mechanisms involved in the development of myeloma bone disease are an increase in osteoclastic bone resorption, and a reduction in bone formation. Myeloma cells are found in close association with sites of active bone resorption, and the interactions between myeloma cells and other cells within the specialized bone marrow microenvironment are essential, both for tumor growth and the development of myeloma bone disease. This review discusses the many different factors which have been implicated in myeloma bone disease, including the evidence for their role in myeloma and subsequent therapeutic implications.

Original publication

DOI

10.1016/j.bone.2008.01.027

Type

Journal article

Journal

Bone

Publication Date

06/2008

Volume

42

Pages

1007 - 1013

Keywords

Animals, Bone Marrow Cells, Bone Resorption, Bone and Bones, Chemokines, Cytokines, Humans, Multiple Myeloma, Osteoblasts, Osteoclasts, Osteogenesis