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In an attempt to combat the pain and damage generated by rheumatoid arthritis (ra), new drugs are being developed to target molecular aspects of the disease process. Recently, a major development has been the use of biologicals (antibodies and soluble receptors) that neutralise the activity of tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1), both of which are involved in disease progression. An increase in our understanding of cell and molecular biology has resulted in the identification and investigation of potential new targets, and also the refinement and improvement of current therapeutic modalities. This review describes therapies that are approved, in clinical trials or under pre-clinical investigation at the laboratory level, particularly focusing on cytokines, although other therapeutic targets of interest are mentioned.

Original publication

DOI

10.1017/S1462399405009488

Type

Journal article

Journal

Expert Rev Mol Med

Publication Date

24/08/2005

Volume

7

Pages

1 - 20

Keywords

Animals, Arthritis, Rheumatoid, Cytokines, Drug Delivery Systems, Humans